Largest US Stock Movers — September 23, 2026
Query: top movers today · data as of 2026-09-23
Built two ranked tables of the most recent session's biggest movers (2026-09-23): 25 top gainers led by enterprise software, cybersecurity and AI-adjacent hardware (FSLY, SECZ, MEI, ACMR, VICR, PANW, CRWD, OKTA), and 25 top losers dominated by clinical-stage biotech plus levered small caps (CGEM, ALKT, RAPP, VOYG, CCOI, EXK, BOBS). Each row includes sector, industry, 1D/1M/6M returns, market cap, relative volume, momentum potential, P/E, days since earnings and distance from the 52-week high, with per-name qualitative comments and a session narrative reflecting the broad breadth washout.
Largest single-session movers on the most recent trading day (September 23, 2026). Gainers skew to enterprise software, cybersecurity and IT hardware; losers are overwhelmingly clinical-stage biotechnology plus levered small caps.
Session Overview
The most recent session was a broad de-risking wave: the average US stock fell roughly 1.6%, decliners outnumbered advancers by more than 3-to-1, and the share of names holding above their 50-day average dropped sharply in a single day. Health Care, Materials, Utilities and Financials led the decline; Energy was the lone large group holding up as crude and natural gas firmed.
What is winning. The gainers list is led by enterprise software, cybersecurity and IT hardware — the one pocket of the market with recurring revenue, net-cash balance sheets and little dependence on the consumer. Palo Alto Networks, CrowdStrike and Okta in the same session is a statement: security and platform software are being treated as non-discretionary enterprise spend even as budgets elsewhere tighten. Behind them sits a second tier of high-beta software names (Fastly, Amplitude, Asana, Klaviyo) bouncing hard on heavy volume — up-days in beaten-down growth names are a classic late-washout tell, but they need follow-through to mean anything. The AI-adjacent hardware thread is visible too, with Vicor (data-center power modules), FormFactor (advanced packaging test) and ACM Research (wafer cleaning) all catching a bid.
What is losing. The losers list is overwhelmingly clinical-stage biotechnology. These are long-duration, pre-revenue assets that carry single-asset clinical risk, ongoing financing needs and thin floats — the first things sold when risk appetite contracts and financing conditions tighten. The pattern is deliberate, not random: several names are recent IPOs with no established shareholder base, several are down 50% or more from their highs, and the group's weakness is a liquidity signal rather than a verdict on any individual pipeline. Outside biotech, a heavily levered fiber operator, a small-cap bank-software vendor tied to regional-bank IT budgets, and a specialty furniture retailer all broke down — consistent with the theme of consumer credit and rate-sensitive small caps leading the downside. Silver miner Endeavour fell with the broader precious-metals unwind as the dollar firmed, a move that reads as cash-raising rather than a change in the commodity outlook.
How to use this screen. Breadth this weak — with far more support breaks than resistance breaks and RSI at multi-week lows — usually needs a repair phase before a durable low forms. The useful signal is not the size of a single day's move but whether the names that held up on relative strength (large-cap security and enterprise cloud, energy majors) continue to attract money while the speculative complex keeps making lower lows. Gainers dominated by low-quality, low-price names are a warning; gainers anchored by profitable franchises are an opportunity.
Top Gainers — Largest 1-Day Gains
| Symbol | Security Name | Sector | Industry | 1D Return | 1M Return | 6M Return | Market Cap ($M) | Relative Volume | Momentum Potential | P/E (TTM) | Days Since Earnings | % From 52W High | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FSLY | Fastly, Inc. | Information Technology | Software - Application | 13.69% | 29.25% | 5.14% | 4,723 | 4.8548 | 76.8 | — | 48 | -11.49% | Edge-network name that has repeatedly been a high-beta proxy for AI traffic growth; revenue reacceleration is the swing factor, and the balance sheet remains the market's key worry. |
| SECZ | Securitize Corp. | Information Technology | Software - Application | 10.46% | 126.14% | — | 2,344 | 3.7764 | — | — | 41 | 0.00% | Tokenization platform riding the digital-asset infrastructure build-out. Very little public float and a short operating history mean moves are magnified — treat the momentum as sentiment-driven rather than fundamentals-confirmed. |
| MEI | Methode Electronics, Inc. | Information Technology | Electronic Components | 9.69% | 5.70% | 155.71% | 528.6161 | 1.8703 | 94.4 | — | 20 | -23.64% | Turnaround auto-parts supplier; the equity is highly sensitive to any sign that restructuring and cost-out are taking hold, which is why it can snap back hard off depressed levels. |
| ACMR | ACM Research, Inc. | Information Technology | Semiconductor Equipment & Materials | 6.42% | 4.30% | 75.68% | 5,619 | 2.5432 | 30.9 | 38.05 | 47 | -36.43% | China-exposed wafer-cleaning equipment maker. It trades on the semiconductor capital-equipment cycle and on China's domestic fab build-out; export-control headlines are the persistent overhang. |
| KVYO | Klaviyo, Inc. Series A | Information Technology | Software - Application | 5.73% | -7.80% | -11.54% | 5,022 | 1.6144 | 40 | — | 48 | -53.29% | Marketing automation platform still finding its footing post-IPO. Bouncing from a deep drawdown, so the question is whether retention and net-new enterprise logos stabilize the growth algorithm. |
| VICR | Vicor Corporation | Information Technology | Electronic Components | 5.52% | 49.04% | 56.88% | 1.306e+04 | 1.8518 | 88.3 | 90.47 | 64 | -25.44% | High-density power modules are a direct beneficiary of AI data-center power delivery — arguably the most structurally levered name on this list, though valuation leaves little room for execution stumbles. |
| ALNT | Allient Inc. | Information Technology | Electronic Components | 5.13% | 22.05% | 74.78% | 1,931 | 0.9792 | 99 | 66.82 | 48 | -0.60% | Small-cap motion and power components maker with heavy industrial and defense exposure; improving order trends and margin recovery are the narrative behind the trend strength. |
| PANW | Palo Alto Networks, Inc. | Information Technology | Software - Infrastructure | 5.00% | 12.08% | 150.17% | 3.217e+05 | 0.9432 | 97.5 | — | 21 | -0.68% | Platformization strategy and subscription security demand keep this name in the non-discretionary bucket for enterprise IT budgets — a rarity in a tape that punished almost everything else. |
| CRWD | CrowdStrike Holdings, Inc. | Information Technology | Software - Infrastructure | 4.97% | 37.66% | 167.17% | 2.688e+05 | 1.3187 | 91.5 | — | 27 | 0.00% | Endpoint and cloud-security leader; net-cash position and high recurring revenue make it a favored hideout when breadth deteriorates. Crowding is the main risk. |
| AMPL | Amplitude, Inc. | Information Technology | Software - Application | 4.68% | 4.60% | 103.78% | 1,824 | 0.7293 | 99.6 | — | 48 | -3.81% | Product-analytics software with a strong growth score but a history of volatile guidance; heavy volume suggests positioning is rebuilding rather than a durable re-rating. |
| BETA | Beta Technologies, Inc. Class A Common Stock | Industrials | Aerospace & Defense | 4.55% | 2.10% | 65.58% | 5,901 | 0.9112 | 85.8 | — | 42 | -33.86% | Electric aircraft developer — a pre-revenue, story-driven aerospace name whose moves track sentiment and certification milestones rather than earnings. |
| CBRL | Cracker Barrel Old Country Stor | Consumer Discretionary | Restaurants | 4.49% | -18.10% | 76.86% | 1,062 | 3.0364 | 39.7 | 41.32 | 0 | -19.51% | Bouncing after a brutal stretch for casual dining and self-inflicted brand missteps; the sector theme has been among the weakest in the market, so this is a countertrend move. |
| OKTA | Okta, Inc. | Information Technology | Software - Infrastructure | 4.45% | 56.80% | 167.54% | 3.59e+04 | 1.5746 | 98.8 | 148.81 | 27 | 0.00% | Identity-security turn; management has stabilized growth and the market is rewarding the recurring-revenue model alongside the rest of the security complex. |
| IONQ | IonQ, Inc. Common Stock | Information Technology | Computer Hardware | 4.42% | 3.60% | 30.09% | 1.723e+04 | 3.5943 | 1.6 | — | 48 | -48.18% | Quantum-computing name with essentially no revenue scale — the move is pure thematic speculation, and the low momentum score reflects how fragile these rallies tend to be. |
| RRR | Red Rock Resorts, Inc. | Consumer Discretionary | Resorts & Casinos | 4.39% | -15.86% | -12.57% | 5,191 | 2.5592 | 53.4 | 17.99 | 49 | -24.32% | Regional casino operator in a rate- and consumer-sensitive segment; the move looks like a short-squeeze bounce within a group that has been sold hard. |
| ASAN | Asana, Inc. | Information Technology | Software - Application | 4.30% | -2.97% | 51.76% | 2,168 | 1.3736 | 77.4 | — | 19 | -37.66% | Work-management software still attempting a turnaround under new cost discipline; a modest bounce does not yet change the competitive pressure from larger suites. |
| FLNC | Fluence Energy, Inc. | Utilities | Utilities - Renewable | 4.26% | -30.20% | -53.07% | 1,409 | 1.421 | 8 | — | 48 | -76.48% | Grid-scale battery storage integrator, deep in drawdown on thin margins and brutal competition; it remains one of the most speculative plays in energy storage. |
| FORM | FormFactor, Inc. | Information Technology | Semiconductor Equipment & Materials | 4.17% | 21.65% | 24.38% | 1.025e+04 | 0.9394 | 20.2 | 90.52 | 55 | -17.93% | Semiconductor test and measurement supplier with exposure to advanced packaging and HBM demand — a bona fide AI-supply-chain link rather than a sympathy mover. |
| VIA | Via Transportation, Inc. | Information Technology | Software - Application | 4.12% | 7.69% | 119.96% | 2,515 | 1.3093 | 89 | — | 48 | -45.23% | Transit-tech software bounce; small float and a short public history make the tape more reflexive than fundamental. |
| DOCU | DocuSign, Inc. | Information Technology | Software - Application | 4.09% | 11.08% | 50.54% | 1.299e+04 | 1.0044 | 65.6 | 45.12 | 19 | -18.07% | E-signature incumbent pivoting to a broader agreement-management platform; the market is testing whether AI features can restart seat expansion. |
| AAON | AAON, Inc. | Industrials | Building Products & Equipment | 3.90% | 8.36% | -1.77% | 6,791 | 1.6453 | 6.8 | 43.35 | 44 | -44.45% | Rooftop HVAC maker with a large data-center cooling opportunity — one of the quieter ways to own the data-center build, though its own momentum score is currently weak. |
| LTH | Life Time Group Holdings, Inc. | Consumer Discretionary | Leisure | 3.88% | -13.25% | 53.70% | 8,865 | 1.9098 | 79.9 | 21.68 | 55 | -13.25% | Premium fitness clubs, one of the worst-performing themes in the market right now; the bounce is countertrend and the consumer-credit backdrop is a live risk. |
| RDVT | Red Violet, Inc. | Information Technology | Software - Application | 3.80% | 8.59% | 103.69% | 1,223 | 1.0105 | 98.7 | 66.84 | 43 | -1.70% | Data-analytics and identity-verification niche with steady government and insurance demand; a consistent cash generator that rarely needs external capital. |
| VEEV | Veeva Systems Inc. | Health Care | Health Information Services | 3.77% | 8.97% | 51.16% | 4.384e+04 | 0.7861 | 99.1 | 48.09 | 27 | -11.58% | Life-sciences cloud incumbent — one of the better-quality growth compounds in health care and a rare green name in a sector that led the day's decline. |
| HUBS | HubSpot, Inc. | Information Technology | Software - Application | 3.74% | -7.43% | -5.01% | 1.157e+04 | 0.9783 | 28.9 | 80.44 | 48 | -56.52% | CRM and marketing hub that has been one of the most de-rated software franchises; the bounce is an oversold reflex unless seat-growth trends stabilize. |
Top Losers — Largest 1-Day Declines
| Symbol | Security Name | Sector | Industry | 1D Return | 1M Return | 6M Return | Market Cap ($M) | Relative Volume | Momentum Potential | P/E (TTM) | Days Since Earnings | % From 52W High | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CGEM | Cullinan Therapeutics, Inc. - Common Stock | Health Care | Biotechnology | -22.15% | -22.69% | 28.98% | 1,037 | 3.1296 | 61.6 | — | 48 | -26.49% | Clinical-stage autoimmune and oncology developer; single-asset clinical risk means any safety or efficacy signal can reprice the equity violently in one session. |
| ALKT | Alkami Technology, Inc. | Information Technology | Software - Application | -19.29% | -28.11% | -8.29% | 1,561 | 4.8845 | 79.7 | — | 55 | -43.15% | Community-bank software vendor tied to regional-bank IT budgets — the exact demand pool that deteriorates fastest when financial-sector credit concerns flare. |
| RAPP | Rapport Therapeutics, Inc. - Common Stock | Health Care | Biotechnology | -17.70% | -30.81% | 24.29% | 1,637 | 1.9162 | 47.1 | — | 49 | -34.99% | CNS-focused biotech with early-stage assets; high cash burn and no approved product leave it fully exposed to financing conditions and clinical headlines. |
| VOYG | Voyager Technologies, Inc. Class A Common Stock | Industrials | Aerospace & Defense | -16.33% | -11.55% | 25.20% | 1,916 | 6.8678 | 4.6 | — | 50 | -39.35% | Defense and space technology developer with a recent listing — small float, thin liquidity and heavy exposure to contract-award timing amplify every macro risk-off session. |
| CBIO | Crescent Biopharma, Inc. - Common Stock | Health Care | Biotechnology | -13.69% | -16.38% | 35.92% | 527.1135 | 1.9501 | 4.3 | — | 55 | -47.41% | Preclinical-stage biopharma with no revenue; these names trade as long-duration options on pipeline data, so they sell off hardest when risk appetite contracts. |
| PBLS | Parabilis Medicines, Inc. - Common Stock | Health Care | Biotechnology | -12.73% | -13.32% | — | 4,115 | 1.7827 | — | — | 41 | -20.18% | Recent biotech IPO with limited public trading history — the absence of an established shareholder base makes price discovery disorderly on down days. |
| CCOI | Cogent Communications Holdings, Inc. - Common Stock | Communication Services | Telecom Services | -12.67% | -14.33% | -55.36% | 416.3839 | 1.1814 | 1.3 | — | 48 | -81.97% | Leveraged fiber and enterprise telecom operator carrying a heavy debt load; falling far below its 52-week high, the equity now behaves like a restructuring proxy. |
| JBIO | Jade Biosciences, Inc. - Common Stock | Health Care | Biotechnology | -12.23% | -31.04% | 4.47% | 935.5176 | 1.5373 | 27.9 | — | 44 | -45.21% | Immunology-focused biotech with a single lead program and minimal revenue — a textbook example of why clinical-stage capital structure matters more than the science on volatile days. |
| VOR | Vor Biopharma Inc. - Common Stock | Health Care | Biotechnology | -11.95% | -14.71% | 59.42% | 1,146 | 2.5177 | 44.9 | — | 43 | -60.24% | Cell-therapy developer dependent on ongoing financing; a deep drawdown signals the market is pricing dilution risk well before any data readout. |
| EXK | Endeavour Silver Corporation | Materials | Silver | -11.89% | -13.94% | 3.23% | 2,549 | 1.6479 | 73.7 | 46.3 | 56 | -34.42% | Silver producer caught in the precious-metals unwind; gold and silver miners were among the weakest groups as the dollar firmed, and the leverage works both ways. |
| CLYM | Climb Bio, Inc. - Common Stock | Health Care | Biotechnology | -11.89% | -23.66% | 87.43% | 719.1019 | 1.4227 | 55.7 | — | 48 | -29.82% | Clinical-stage immune and inflammatory disease biotech; speculative positioning and a small float mean the stock has no natural buyer base on a risk-off day. |
| APMD | Apnimed, Inc. | Health Care | Biotechnology | -11.84% | -12.25% | — | 936.2762 | 1.5107 | — | — | 14 | -30.91% | Late-stage developer targeting sleep apnea with a novel therapeutic — a regulatory decision path that has historically been unforgiving for this category. |
| EOSE | Eos Energy Enterprises, Inc. - Common Stock | Industrials | Electrical Equipment & Parts | -11.82% | 3.47% | -29.67% | 1,295 | 1.1532 | 0.2 | — | 49 | -81.34% | Zinc-based long-duration storage developer with negative margins and recurring capital needs; among the most speculative names in the power-storage complex. |
| PRME | Prime Medicine, Inc. - Common Stock | Health Care | Biotechnology | -11.58% | -3.69% | -11.08% | 567.7096 | 1.0543 | 6.3 | — | 48 | -53.07% | Gene-editing platform with multi-year programs and no near-term revenue; the equity is a long-duration asset most sensitive to discount-rate and risk-appetite shifts. |
| BLSM | BlossomHill Therapeutics, Inc. Common Stock | — | — | -11.52% | 39.36% | — | 710.0749 | 0.7955 | — | — | — | -16.70% | Small oncology-focused biotech with essentially no revenue base — the violent swings reflect an illiquid shareholder register rather than fundamental news. |
| BOBS | Bob's Discount Furniture, Inc. | Consumer Discretionary | Specialty Retail | -11.25% | -23.89% | 14.13% | 1,773 | 1.567 | 67.3 | 13.3 | 48 | -39.77% | Furniture retailer selling into a weakening discretionary-spending backdrop; specialty retail has been one of the weakest themes in the market and leverage magnifies the downside. |
| ODTX | Odyssey Therapeutics, Inc. - Common Stock | Health Care | Biotechnology | -11.05% | -17.46% | — | 997.695 | 0.9331 | — | — | 48 | -27.82% | Early-stage biotech with a thin pipeline and minimal trading liquidity; declines of this magnitude typically reflect position unwinds rather than a change in intrinsic value. |
| RLMD | Relmada Therapeutics, Inc. - Common Stock | Health Care | Biotechnology | -10.85% | -17.47% | -38.03% | 403.212 | 0.8089 | 21.2 | — | 47 | -51.91% | CNS-focused microcap with a history of clinical setbacks and repeated capital raises — a persistent dilution overhang that keeps long-term holders cautious. |
| AKTS | Aktis Oncology, Inc. - Common stock | Health Care | Biotechnology | -10.81% | -24.10% | 5.85% | 1,097 | 1.4281 | 61.9 | — | 40 | -38.81% | Radiopharmaceutical oncology developer; capital-intensive manufacturing plus clinical timelines make it dependent on continued financing access. |
| ANRO | Alto Neuroscience, Inc. Common Stock | Health Care | Biotechnology | -10.66% | -24.14% | 36.21% | 1,079 | 1.2022 | 76.3 | — | 41 | -24.95% | Neuropsychiatry biotech with no approved product; the pipeline is option-like and the shares trade as a volatility instrument in risk-off sessions. |
| TRAX | First Tracks Biotherapeutics, Inc. - Ordinary Shares | Health Care | Biotechnology | -10.65% | -15.30% | — | 1,310 | 0.8384 | — | — | 41 | -23.50% | Newly listed biotech — recent IPOs with limited history are the first to be liquidated when investors trim small-cap risk. |
| STOK | Stoke Therapeutics, Inc. - Common Stock | Health Care | Biotechnology | -10.58% | -19.21% | -21.33% | 1,685 | 1.305 | 42.7 | — | 50 | -31.92% | RNA-based genetic medicine developer; platform stories with distant revenue require a supportive financing market, which is exactly what is tightening here. |
| ZBIO | Zenas BioPharma, Inc. - Common Stock | Health Care | Biotechnology | -10.35% | -6.38% | 40.69% | 1,931 | 0.682 | 68.1 | — | 41 | -31.36% | Autoimmune and inflammation biotech relying on partnership economics; headline risk around trial design and partner decisions keeps the equity unstable. |
| ERAS | Erasca, Inc. - Common Stock | Health Care | Biotechnology | -10.32% | -20.77% | -4.94% | 4,877 | 1.0337 | 60.6 | — | 42 | -37.94% | RAS-driven oncology developer; the KRAS space is crowded and competitive, so the shares carry both clinical and competitive-commercialization risk. |
| SLDB | Solid Biosciences Inc. - Common Stock | Health Care | Biotechnology | -10.09% | -12.45% | 20.06% | 859.9465 | 0.9433 | 33.6 | — | 47 | -28.07% | Gene-therapy developer for rare neuromuscular disease with heavy manufacturing cost structure — one of the most capital-hungry corners of biotech in a risk-off tape. |
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